Applications

Single-cell RNA sequencing (scRNA-Seq) has enabled unprecedented insight into the biology of individual cells and tissue complexity across a broad range of discovery and disease areas. Below are some of the application areas where the the accessibility, precision, and sensitivity of our PIPseqTM technology can enable new research and discoveries.

Cancer

Understanding the differences in gene transcription between healthy and diseased cells are fundamental to cancer pathology.  scRNA-Seq has been a vital tool for understanding: 

  • Differential gene expression
  • Novel cancer biomarkers
  • Tumor heterogeneity 
  • Drug resistance
  • Cancer immunotherapy

Immunology

The immune system is composed of a complex hierarchy of diverse cell types that work in concert to identify, target, and eliminate pathogens. scRNA-Seq allows for:

  • Identification of previously unknown sub-populations of immune cells
  • Understanding developmental and differentiation pathways in immune cell populations
  • Evaluation of the roles and functions of immune cell populations

Neuroscience

Neuronal tissues comprise a complex organization of diverse cell types that continuously reorganize and remodel throughout an organism’s lifetime. scRNA-Seq has become a valuable tool to catalog the true diversity of neuronal cell populations with unprecedented transcriptional sensitivity providing insight into:

  • Neurodevelopmental and neurodegenerative diseases
  • Previously unknown roles of specific neuronal populations
  • The effect of neuro-immune cells on disease and development

Infectious Disease

Pathogens such as bacteria or viruses cause disease through uncontrolled infection and propagation in a host. Specific pathogens may target individual tissues or cells, and may evade immune system control through a variety of mechanisms.  scRNA-Seq allows for unprecedented insight to the interactions between pathogens and hosts at the cellular level for:

  • Sepsis
  • Viral infections
  • Pathogen – host interactions in high-risk organisms studied in high-containment laboratories

Featured Product

PIPseq™ 3”
Single Cell RNA Kit

  • Cost effectively profile up to 2000 single cells per sample
  • Includes sample processing + library preparation reagents
  • Compatible with Illumina sequencing
  • Access to user-friendly downstream analysis portal